Methyl 1-(2-oxoethyl)cyclohexanecarboxylate → 1-{2-[2-methyl-6-((2S,3'R)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-ylamino]-ethyl}-cyclohexanecarboxylic acid methyl ester

Participants

Reaction Steps

The title compound was synthesized in essentially the same manner using the procedures as set forth in Step 1 of Example 1, by condensing 1-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester (41 mg, 0.22 mmol) and 2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-ylamine to obtain 94 mg of a crude solid, which was used in the next step of the reaction without further purification.

Provenance & Evidence