Formic Acid → HCID 131731728, compound

Participants

Reaction Steps

A formic acid (2.7 mL, 70.4 mmol) solution of methyl 5-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H imidazo[4,5-b]pyridin-2-yl]oxy}-2-methylbenzoate (140 mg, 0.23 mmol) and saturated potassium bisulfate (0.27 mL) was stirred at 80° C. for 1 h. The reaction was partitioned between EtOAc and brine. The organic layer was separated, and concentrated to give methyl 5-{[5-(biphenyl-4-yl)-6-chloro-1-H imidazo[4,5-b]pyridin-2-yl]oxy}-2-methylbenzoate as a white solid, which was used in the next step without further purification. LC-MS: calculated for C27H20ClN3O3 456.89, observed m/e: 470.2 (M+H)+ (Rt 2.3/4 min).

Provenance & Evidence