HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2,5,6-Trichloropyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 4-Pyrimidinamine, 2,6-dichloro- | HCID 82387 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,5,6-Trichloropyrimidin-4-amine | HCID 15850196 | 115.7% |
Reaction Steps
1 g (6.1 mmol) of 4-amino-2,6-dichloropyrimidine were dissolved in 5 ml of DMF. To this solution was added 0.98 g (7.32 mmol) of N-chlorosuccinimide. The solution was poured onto 100 ml of cool water. The formed precipitate was filtered, washed with water and dried to yield 1.4 g (80%) of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796284B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-a5a924e45c804dd9bce80262e68f08cf |
| Source note | uspto-grants-2014_08 |