反应详情

A solution of 0.10 g (0.37 mmol) of 5-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidine-4-amine (Intermediate 5) and 0.05 g (0.77 mmol) of sodium azide in dioxane (10 mL) was stirred at 80° C. for 6 h. The solvent was then evaporated, and the residue dissolved in methanol, Pd on charcoal added (10 mg) and hydrogenated for 30 min. The solvent was again evaporated and the residue crystallizes from ethanol.

1. customThe solvent was then evaporated
2. dissolutionthe residue dissolved in methanol
3. additionPd on charcoal added (10 mg)
4. customThe solvent was again evaporated
5. customthe residue crystallizes from ethanol