Ammonia → HCID 178513697, compound

HRID 2401177Notes

Reaction equation

HRID 2401177 reaction equation
[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10]CC)=O)[CH:3]=1.[NH3:13]>>[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH2:13])=[O:10])[CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178469368HCID 178469368, compound2×

Product 1

HCID 178513697HCID 178513697, compoundYield 68.4%

Procedure

Ethyl 6-hydroxy-4-pyrimidinecarboxylate (Intermediate 6, 0.995 g, 5.92 mmol) was treated with 0.88 ammonia solution (9.95 mL, 460 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 18 hours. The resulting solid was collected by filtration, taken up in toluene and the solvent removed under reduced pressure to give the title compound as a yellow solid (563 mg);

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-8707f8fbf2ae48cd97769a773ef24e81
Source dataset
uspto-grants-2014_08
Patent number
US08796283B2

Reaction notes

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