反应详情

温度

-78 °C

To a stirred solution of DAST (0.153 mL, 1.159 mmol) in DCM (5 mL) was added 2-(6-chloro-4-pyrimidinyl)-2-propanol (Intermediate 28, 100 mg, 0.579 mmol) dissolved in DCM (5 mL) dropwise, and the resulting mixture stirred under argon at −78° C. for 4 hrs. The reaction mixture was quenched with excess saturated sodium bicarbonate solution (50 mL) and extracted with DCM (2×20 mL). The organic layers were collected and solvent was removed gently in vacuo. Crude product in DCM was taken into the next reaction without further purification.

1. customThe reaction mixture was quenched with excess saturated sodium bicarbonate solution (50 mL)
2. extractionextracted with DCM (2×20 mL)
3. customThe organic layers were collected
4. customsolvent was removed gently in vacuo
5. customCrude product in DCM was taken into the next reaction without further purification