Water → HCID 178437741, compound

A mixture of 25% sodium methoxide in methanol (24.16 ml, 100 mmol) in methanol was stirred during the addition of formamidine acetate (5.73 g, 55.0 mmol) and methyl 2-methyl-3-oxopentanoate (Intermediate 39, 7.21 g, 50 mmol) and the reaction mixture was stirred at room temperature for 3 hours. Water (20 ml) and acetic acid (20 ml) were then added and the solution was concentrated under reduced pressure removing most of the organic solvent from the reaction mixture which was then washed with brine and extracted with ethyl acetate (×3). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure. The resulting yellow residue was purified by trituration with ether, the resulting colourless solid was collected, washed with ether and dried to give the title compound as a clear solid (2.8 g);

1. concentrationthe solution was concentrated under reduced pressure
2. customremoving most of the organic solvent from the reaction mixture which
3. washwas then washed with brine
4. extractionextracted with ethyl acetate (×3)
5. customdried under magnesium sulfate
6. customevaporated under reduced pressure
7. customThe resulting yellow residue was purified by trituration with ether
8. customthe resulting colourless solid was collected
9. washwashed with ether
10. customdried

ORD record

ord-a38a031c5ef34c9e9102074b9128a0f4

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08796283B2