Hydrochloric Acid → HCID 83854098, compound

Participants

Reaction Steps

4-Chloro-6-[1-(ethyloxy)ethenyl]-5-methylpyrimidine (Intermediate 42, 1.49 g, 7.50 mmol) was dissolved in acetone (75 ml), treated with 2M aqueous hydrochloric acid solution (11.25 ml, 22.50 mmol) and the resulting mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure. The residue was neutralised with aqueous saturated sodium bicarbonate solution and extracted with ethyl acetate (×2). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a yellow oil (947 mg);

Provenance & Evidence