Sodium borohydride → HCID 83854097, compound

Participants

Reaction Steps

1-(6-Chloro-5-methyl-4-pyrimidinyl)ethanone (Intermediate 43, 500 mg, 2.93 mmol) was dissolved in ethanol (10.0 mL), treated with sodium borohydride (111 mg, 2.93 mmol) and the resulting mixture was stirred at room temperature under argon for 2 hours. The solvent was removed under reduced pressure and the residue was diluted with water and extracted with ethyl acetate (×3). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a white crude solid (380 mg) which was used without further purification;

Provenance & Evidence