Diisopropylethylamine → 8-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid (2'-acetylamino-biphenyl-3-yl)-amide

Participants

Reaction Steps

DIEA (0.013 mL, 0.073 mmol) was added to 8-trifluoromethoxy-3-carboxy-coumarin (0.018 g, 0.066 mmol) and HATU (0.028 g, 0.073 mmol) in 0.36 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, N-(3′-Amino-biphenyl-2-yl)-acetamide (0.015 g, 0.066 mmol) was added and allowed to react overnight and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 0.008 g of product in 26% yield: LCMS (ESI) m/z 483 (MH+).

Provenance & Evidence