N-methyl-2-pyrrolidone → HCID 51356421, compound

Participants

Reaction Conditions

Reaction Steps

1-[2-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]methanamine (Intermediate 5, 129 mg, 0.6 mmol), 4-chloro-6-ethyl-5-methylpyrimidine (Intermediate 41, 141 mg, 0.900 mmol) and DIPEA (0.210 mL, 1.200 mmol) were added together with N-methyl-2-pyrrolidone (1 mL) and the resulting mixture was stirred and heated to 120° C. for 6 hours. The reaction mixture was diluted with ethyl acetate and washed with sodium hydrogen carbonate solution, water and brine. The organic layer was separated, dried under magnesium sulfate and evaporated under reduced pressure. The residue was purified by MDAP. Product containing fractions were combined and evaporated under reduced pressure. The resulting solid was triturated with ether/isohexane (1:1) and the resulting solid was collected and dried affording the title compound (60 mg);

Provenance & Evidence