Sodium hydride → HCID 86705172, compound

Participants

Reaction Steps

Sodium hydride (60%, 27 mg) was added to a solution of (4S)-1-(4-methoxyphenyl)-4-propylimidazolidin-2-one (32 mg) in DMF (1.5 mL), and the mixture was stirred at room temperature for 15 min. To the mixture was added 2-chloro-N-[4-(trifluoromethyl)pyridin-2-yl]acetamide (39 mg), and the resulting mixture was stirred for 15 hr. Thereafter, the reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by preparative HPLC, and further the resulting solid was washed with isopropyl ether to afford 2-[(55)-3-(4-methoxyphenyl)-2-oxo-5-propylimidazolidin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]acetamide (19 mg).

Provenance & Evidence