Hydrochloride methanol → HCID 86705175, compound

HRID 2401275Notes

Reaction equation

HRID 2401275 reaction equation
[F:1][C@H:2]([C@H:5]1[CH2:9][O:8]C(C)(C)[N:6]1C([O-])=O)[CH2:3][CH3:4].[ClH:15].CO>>[ClH:15].[NH2:6][C@@H:5]([C@@H:2]([F:1])[CH2:3][CH3:4])[CH2:9][OH:8]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86705177HCID 86705177, compound

Product 1

HCID 86705175HCID 86705175, compound

Procedure

A 5-10% HCl/methanol solution (70 mL) was added to tert-butyl((4R)-4-[(1S)-1-fluoropropyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (4.9 g), and the mixture was stirred at room temperature overnight. The solvent was distilled off under reduced pressure to afford the title compound (2.96 g).

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-9bc119acc84346909399626336dc247d
Source dataset
uspto-grants-2014_08
Patent number
US08796272B2

Reaction notes

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