Water → HCID 86705179, compound

Participants

Reaction Steps

Sodium hydride (about 60%, 546 mg) was added to a solution of benzyl[(2R,3S)-3-fluoro-1-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]amino}pentan-2-yl]carbamate (2.85 g) in THF (35 mL), and the mixture was stirred at room temperature for 6 hr. Water was added to the reaction mixture, the resulting mixture was extracted with ethyl acetate, and the organic layer was washed with brine. The solvent was distilled off under reduced pressure, and the residue was purified by column chromatography (silica gel cartridge, hexane/ethyl acetate=80:20-40:60) to afford the title compound (2.07 g).

Provenance & Evidence