HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 86705186, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86705187 | HCID 86705187 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 86705186 | HCID 86705186 | 82.7% |
Reaction Steps
N,N-diisopropylethylamine (0.06 mL), HATU (142 mg), and 3,5-difluoroaniline (48 mg) were added to a solution of [3-(6-methoxypyridin-3-yl)-2-oxo-5-propylimidazolidin-1-yl]acetic acid (100 mg) in chloroform (2 mL), and the mixture was stirred at room temperature overnight. Saturated aqueous sodium hydrogen carbonate solution was added thereto, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. After the desiccant was filtered off, the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel cartridge, hexane/ethyl acetate) to afford the title compound (114 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796272B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-5abc00f3e22546c1aa9a3dfb1ba12ee0 |
| Source note | uspto-grants-2014_08 |