Sodium Bicarbonate → HCID 86705195, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-(6-bromopyridin-3-yl)-2-{(5S)-5-(2-methylpropyl)-2-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]imidazolidin-1-yl}acetamide (78 mg), tributyl(1-ethoxyvinyl)tin (145 mg), bis(triphenylphosphine)palladium(II) dichloride (22 mg), and copper(I) iodide (6.3 mg) in acetonitrile (1.5 mL) was stirred under irradiation with microwave at 150° C. for 2 hr. Saturated aqueous sodium hydrogen carbonate solution was added thereto, followed by extraction with chloroform. The organic layer was separated by phase separation cartridge, and the solvent was distilled off under reduced pressure. The residue was purified by preparative HPLC, 1M HCl (1.5 mL) was added to the resulting product, and the mixture was stirred at room temperature for 10 min. The mixture was made basic with saturated sodium hydrogen carbonate, followed by extraction with chloroform, and the solvent was distilled off under reduced pressure to afford the title compound (60 mg).

Provenance & Evidence