Potassium Carbonate → HCID 86705197, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(6-bromopyridin-3-yl)-2-{(5S)-5-(2-methylpropyl)-2-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]imidazolidin-1-yl}acetamide (50 mg), cyclopropyl boronic acid (17 mg), palladium acetate (1.1 mg), triphenylphosphine (2.6 mg), and potassium carbonate (41 mg) in toluene/water (=20:1, 1.5 mL) was stirred at 110° C. for 9 hr. Additional cyclopropyl boronic acid (35 mg) was added thereto, and the mixture was further stirred at 110° C. for 6 hr, followed by at 80° C. for 2 hr. The solvent was distilled off under reduced pressure, and the residue was purified by preparative HPLC. After further purification by PTLC(NH silica gel, hexane/ethyl acetate=1:1), the resulting solid was washed with isopropyl ether to afford the title compound (2.5 mg).

Provenance & Evidence