HCID 67192531, compound → HCID 67192793, compound

Participants

Reaction Steps

2-(3-Acetyl-phenoxy)-8-cyclopentyl-1-propyl-1,7-dihydro-purin-6-one (0.08 g, 0.21 mmol), was taken in THF. To this was added methyl magnesium bromide (30 μl, 0.25 mmol) drop wise at −70° C. and stirred for 2 hours. Another lot of methyl magnesium bromide (30 μl, 0.25 mmol) was added and stirred further for 2 hours. Reaction was quenched with saturated NH4Cl solution and concentrated to evaporate THF and residue was dissolved in ethyl acetate, washed with water followed by brine and dried over anhydrous Na2SO4. The crude product was purified by preparative TLC to give the product (0.027 g) as an off white solid in 32% yield.

Provenance & Evidence