Sodium Carbonate → HCID 136350313, compound

Participants

Reaction Steps

To a solution of 2,6-dichloro-8-cyclopentyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-purine (0.12 g, 0.31 mmol) in dioxane (5 ml) was added aqueous solution of sodium carbonate (0.012 g, 1.24 mmol, in 4 ml water). Reaction mixture was refluxed overnight. Reaction mixture was concentrated and water was added in it and it was extracted with ethyl acetate. Ethyl acetate layer was washed with brine and water, dried over sodium sulphate, filtered and concentrated. Residue obtained was washed with ether to obtained 2-chloro-8-cyclopentyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.1 g, 87%) as white solid.

Provenance & Evidence