1-Methylpyrrolidine → HCID 67194093, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-8-cyclopentyl-1-isobutyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.11 g, 0.259 mmol), N-methylpyrrolidine (1 ml), potassium carbonate (0.11 g, 0.778 mmol) and 2-methyl 3-hydroxy pyridine (0.034 g, 0.31 mmol), was heated at 85-90° C. overnight. Reaction mixture was cooled room temperature, diluted with water (10 ml), extracted with ethyl acetate. The ethyl acetate layer was washed with brine and water, dried over sodium sulphate, filtered and concentrated to obtain 8-cyclopentyl-1-isobutyl-2-(2-methyl-pyridin-3-yloxy)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.11 g, 75%) as crude oil.

Provenance & Evidence