Hydrochloric Acid → HCID 52934384, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-cyclopentyl-1-isobutyl-2-(2-methyl-pyridin-3-yloxy)-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.11 g, 0.214 mmol), 2N HCl (2.5 ml), ethanol (2.5 ml) was heated at 85° C. for 4 hours. The mixture was cooled and the solvent was evaporated. The residue was diluted with water (10 ml). The aqueous layer was extracted with ethyl acetate. The organic layer was washed with saturated brine solution, dried over sodium sulphate and concentrated. The residue was purified by column chromatography to provide 8-Cyclopentyl-1-isobutyl-2-(2-methyl-pyridin-3-yloxy)-1,7-dihydro-purin-6-one (0.01 g) as white solid.

Provenance & Evidence