Methanol → HCID 67193251, compound

Participants

Reaction Steps

To a solution of 8-cyclopentyl-2-chloro-1-propyl-1,7-dihydro-purin-6-one (0.06 g, 0.21 mmol) in methanol (2 ml) was added NaH (60% dispersion in mineral oil, 0.085 g, 2.14 mmol) under nitrogen atmosphere and the reaction mixture was refluxed for 3 hours. After cooling to room temperature the reaction mixture was concentrated under reduced pressure. Water (10 ml) was added to the residue and the product was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by preparative TLC using 2% methanol in dichloromethane as solvent system to give the product (0.013 g, 22%) as a white solid.

Provenance & Evidence