Water → HCID 67192387, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-cyclopentyl-2-chloro-1-propyl-1,7-dihydro-purin-6-one (0.06 g, 0.21 mmol) in N-methyl-pyrrolidone (1 ml) was added aniline (0.20 g, 2.14 mmol) and the mixture was heated at 150° C. overnight. Water was added to the reaction mixture and the product was extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by preparative TLC using 5% methanol in dichloromethane to give the product (0.034 g, 47%) as a brown solid.

Provenance & Evidence