Potassium Carbonate → HCID 67195298, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-8-(hexahydro-2,5-methano-pentalen-3a-yl)-1-propyl-1,7-dihydro-purin-6-one (0.10 g, 0.30 mmol) in N-methyl-2-pyrrolidone (0.3 ml) was added K2CO3 (0.062 g, 0.45 mmol) followed by 4-trifluoromethyl phenol and the reaction mixture was heated at 130° C. overnight. The reaction mixture was diluted with ethyl acetate and water. The layers were separated and ethyl acetate layer was washed with water. The ethyl acetate layer was dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by column chromatography using 5% methanol in DCM as the eluant to give the product (0.013 g, 9%) as a brown solid.

Provenance & Evidence