3-Fluorophenylalanine → HCID 52936160, compound

Participants

Reaction Steps

To a solution of 2-Amino-3-(3-fluoro-phenyl)-propionic acid (112 mg, 0.612 mmol) and K2CO3 (140 mg, 1.02 mmol) in water (5 ml) was added 2-Chloro-8-cyclohexyl-1-propyl-1,7-dihydro-purin-6-one (150 mg, 0.51 mmol). The reaction mixture was stirred at refluxing temperature for overnight. Aqueous ammonium chloride was added to the reaction mixture. The solid obtained was filtered and dried. The crude product was purified by preparative HPLC to obtain 4 mg (˜2%) of pure product as pink solid.

Provenance & Evidence