Water → HCID 52933693, compound

Participants

Reaction Steps

To a solution of 8-cyclopent-3-enyl-2-(3-methoxy-phenoxy)-1-propyl-1,7-dihydro-purin-6-one (0.075 g, 0.20 mmol) and N-methyl morpholine N-oxide (0.036 g, 0.30 mmol) in a mixture of acetone, t-butanol, and water in the ratio 60:1:1, catalytic amount of osmium tetroxide (2 mg) was added. Reaction mixture was allowed to stir for 2 hours at room temperature. The reaction mixture was quenched with saturated sodium sulphite solution and was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by preparative TLC using 3% methanol in DCM to give the product (0.014 g, 13%) as light green solid.

Provenance & Evidence