Ammonia → HCID 67195016, compound

Participants

Reaction Steps

A mixture of 3-(8-Cyclopentyl-6-oxo-1-propyl-6,7-dihydro-1H-purin-2-yloxy)-benzoic acid methyl ester (0.07 g, 0.17 mmol, 1.0 eq) and 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (0.034 g, 0.247 m·mol, 1.4 eq) was taken in THF. To this was added Liq.NH3 (˜3 g) through septum in sealed tube at −78° C. and then heated at 50° C. overnight. Crude reaction mixture was purified by preparative TLC to give the product as a white solid (0.04 g) in 60% yield.

Provenance & Evidence