Methanol → HCID 67811908, compound

Participants

Reaction Conditions

Reaction Steps

To a round bottomed flask was added (4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)methyl benzoate (32.7 mg, 0.076 mmol), THF (3 mL), MeOH (3 mL), and water (1.5 mL). This solution was cooled to 0° C. before addition of Lithium Hydroxide Monohydrate (9.53 mg, 0.227 mmol) and the reaction stirred at 0° C. for 1 h before diluting with water and EtOAc. The layers were separated and the aqueous extracted with EtOAc (3×). The combined organics were washed with brine, dried over Na2SO4, filtered, and concentrated to afford crude (4-chlorophenyl)(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone.

Provenance & Evidence