Dichloromethane → HCID 86666712, compound

Participants

Reaction Conditions

Reaction Steps

To a round bottomed flask was added crude (4-chlorophenyl)(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone (24.9 mg, 0.076 mmol), DCM (2 mL), and Et3N (21.18 μl, 0.152 mmol). This solution was cooled to 0° C. before addition of MsCl (7.10 μl, 0.091 mmol) and the reaction stirred at 0° C. for 30 min before diluting with water and extracting with DCM. The combined organics were dried over Na2SO4, filtered, and concentrated to afford crude (4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)methyl methanesulfonate.

Provenance & Evidence