Trimethylphosphine → HCID 67951243, compound

Participants

Reaction Steps

To a resealable vial was added crude (2-(5-(azidomethyl)-3-methylisoxazol-4-yl)phenyl) (4-chlorophenyl)methanone (27 mg, 0.077 mmol) and toluene. The vial was sealed and placed under N2 before addition of trimethylphosphine solution (92 μl, 1 M toluene, 0.092 mmol). The reaction was stirred at room temperature for 2 h before purifying via Biotage (10 g, EtOAc/hex) to afford 6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepine. 1H NMR (400 MHz, Acetone) δ 7.78-7.84 (m, 1H), 7.65-7.74 (m, 1H), 7.34-7.47 (m, 6H), 4.62 (br. s, 2H), 2.54 (s, 3H). LC/MS m/z 309 [M+H]+.

Provenance & Evidence