Phenol → 6-(4-Chlorophenyl)-1-methyl-7-phenoxy-4H-isoxazolo[5,4-c]pyrido[4,3-e]azepine

Participants

Role	Name	HCID	Charge
Reactant	Phenol	HCID 996	—
Reactant	6-(4-chlorophenyl)-7-methoxy-1-methyl-4H-isoxazolo[5,4-c]pyrido[4,3-e]azepine	HCID 57344518	—
Product	6-(4-Chlorophenyl)-1-methyl-7-phenoxy-4H-isoxazolo[5,4-c]pyrido[4,3-e]azepine	HCID 57388931	—

Reaction Steps

A procedure similar to 6-(4-chlorophenyl)-7-methoxy-1-methyl-4H-isoxazolo[5,4-c]pyrido[4,3-e]azepine (Compound 170) was followed, except that phenol was used instead of methanol. LC/MS m/z 402 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 8.33 (d, J=5.40 Hz, 1H), 7.56 (d, J=5.40 Hz, 1H), 7.41 (s, 4H), 7.31 (tt, J=2.20, 8.00 Hz, 2H), 7.14 (tt, J=1.40, 7.50 Hz, 1H), 6.79 (d, J=8.00 Hz, 2H), 5.31 (d, J=13.3 Hz, 1H), 4.25 (d, J=13.29 Hz, 1H), 2.58 (s, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08796261B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-6200cdcae8734179a0a02360d3cbdfd2
Source note	uspto-grants-2014_08