HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-chloroisonicotinic acid → 8-Chloro-6-(4-chlorophenyl)-1-methyl-4H-isoxazolo[5,4-c]pyrido[3,4-e]azepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-chloroisonicotinic acid | HCID 20137907 | — |
| Reactant | 3-Bromo-6-chloropyridine-2-carboxylic acid | HCID 26966732 | — |
| Reactant | 8-Chloro-6-(4-chlorophenyl)-1-methyl-4H-isoxazolo[5,4-c]pyrido[3,2-e]azepine | HCID 86666727 | — |
| Product | 8-Chloro-6-(4-chlorophenyl)-1-methyl-4H-isoxazolo[5,4-c]pyrido[3,4-e]azepine | HCID 86666728 | — |
Reaction Steps
A sequence similar to 8-chloro-6-(4-chlorophenyl)-1-methyl-4H-isoxazolo[5,4-c]pyrido[3,2-e]azepine (Compound 240) was followed, except that 5-bromo-2-chloroisonicotinic acid was used as commercially available starting material instead of 3-bromo-6-chloropicolinic acid. LC/MS m/z 344 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 8.93 (d, J=0.80 Hz, 1H), 7.49 (td, J=2.10, 8.70 Hz, 2H), 7.46-7.42 (m, 3H), 4.77 (br. s, 2H), 2.57 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796261B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9ef06b241a8e4363bacbcd1e890537bd |
| Source note | uspto-grants-2014_08 |