Hydrochloric Acid → HCID 86649361, compound

Participants

Reaction Steps

A stirred solution of tert-butyl 3-(2-aminopyrimidin-4-ylamino)propyl(methyl)carbamate (Example 7A, 40 mg, 0.1422 mmol) in methanol (0.5 mL) was treated with a 4M solution of HCl in dioxane (0.5 mL, 2.0000 mmol). After stirring at ambient temperature for 18 hours, volatiles were removed under reduced pressure to give a white solid that was crystallized methanol/ether. White crystals were collected by filtration to provide N4-(3-(methylamino)propyl)pyrimidine-2,4-diamine dihydrochloride (6.0 mg, 16.6% yield). 1H NMR (300 MHz, CD3OD) δ ppm 2.01 (pentet, J=7 Hz, 2H), 2.72 (s, 3H), 3.07 (t, J=7 Hz, 2H), 3.58 (t, J=7 Hz, 2H), 6.13 (d, J=7 Hz, 1H), 7.58 (d, J=7 Hz, 1H). MS (DCl—NH3) m/z=182 (M+H)+.

Provenance & Evidence