HCID 86687928, compound → HCID 86687929, compound

HRID 2401474Notes

Reaction equation

HRID 2401474 reaction equation
[CH3:1][O:2][C:3]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][N:6]([CH3:16])[C:7]2=[O:15]>CO.[Pd]>[NH2:12][C:11]1[C:3]([O:2][CH3:1])=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:15])[N:6]([CH3:16])[CH2:5]2

Participants

4

Reactant 1

HCID 86687928HCID 86687928, compound

Product 1

HCID 86687929HCID 86687929, compoundYield 52%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 4-methoxy-2-methyl-5-nitroisoindolin-1-one (155 mg, 0.7 mmol) in MeOH (10 mL) was added Pd/C (60 mg). The mixture was stirred at 50° C. under H2 for 6 h. The resulting suspension was filtered. The filtrate was concentrated under reduced pressure to afford 5-amino-4-methoxy-2-methylisoindolin-1-one (70 mg, yield 52%). m/z (ES+APCI)+: [M+H]+193.1.

Workup

  1. filtrationThe resulting suspension was filtered
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-07c906a1c0b54aa19a8d7a73999ed3bf
Source dataset
uspto-grants-2014_08
Patent number
US08796296B2

Reaction notes

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