2-Amino-5-fluoropyridine → HCID 69937644, compound

Participants

Reaction Steps

5-fluoropyridin-2-amine (4.2 mg, 0.037 mmol, 1.2 eq) was dissolved in THF (0.20 mL), and potassium bis(trimethylsilyl)amide (13 mg, 0.066 mmol, 2.1 eq) was added. The reaction was stirred at rt for 5 minutes. Compound 9 (8.0 mg, 0.031 mmol, 1.0 eq) was dissolved in THF (0.20 mL) and added to the reaction mixture. The reaction was stirred at rt for 30 minutes, dried on air concentrator, and purified by reverse-phase preparatory HPLC to afford 0.7 mg (10%) of the title compound as a mono-TFA salt: 1H NMR (400 MHz, DMSO-d6) δ 9.10 (s, 1H), 8.78 (s, 2H), 8.41 (d, J=3.0, 1H), 8.27 (t, J=1.3 Hz, 1H), 8.19 (dd, J=9.2, 4.1 Hz, 1H), 8.03-8.00 (m, 2H), 7.81 (td, J=8.7, 3.0 Hz, 1H); ES-MS [M+1]+:336.1.

Provenance & Evidence