HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate → HCID 24828980, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate | HCID 49760270 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 24828980 | HCID 24828980 | 71.7% |
Reaction Steps
To a solution of 4-(4-chlorophenyl)-4-cyanopiperidin-1-carboxylic acid tert-butyl ester (0.355 g, 1.107 mmol) in ethanol (20 ml) at room temperature was added Raney Nickel (Raney Nickel 2800, 1 ml) and the suspension stirred under 1 atmosphere of hydrogen for 20 hours. The suspension was filtered through celite and the filtrate concentrated to give the amine as an oil (0.258 g, 69%). LC/MS: (LCT) Rt 5.02 [M-But-NH2]+324.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796293B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-a7c930605003400aae6b5851855a69ad |
| Source note | uspto-grants-2014_08 |