Sodium Chloride → Ethyl 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

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Reaction Conditions

Reaction Steps

20.00 g (85.38 mmol) of ethyl 8-hydroxy-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate Example 17A were initially charged with 19.44 g (93.91 mmol) of 2,6-difluorobenzyl bromide and 61.20 g (187.83 mmol) of caesium carbonate in 1.18 l of DMF and stirred at 60° C. for 5 h. The flask content was poured 6.4 l of 10% strength aqueous sodium chloride solution and extracted twice with ethyl acetate. The combined organic phases were washed once with 854 ml of 10% strength aqueous sodium chloride solution, dried, evaporated and dried under high vacuum at RT overnight. This gave 28.2 g (92% of theory; purity about 90%) of the title compound.

Provenance & Evidence