Hydrochloric Acid → HCID 73673718, compound

Participants

Reaction Steps

67 mg of methyl 8-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}-amino)octanoate Example 16 (0.15 mmol, 1 equivalent) were dissolved in 2.5 ml of THF, and 0.3 ml of 1 M lithium hydroxide solution in water (0.3 mmol, 2 equivalents) was added. The mixture was stirred at RT overnight and then acidified with 1 M aq. hydrochloric acid and concentrated. The residue was dissolved in methanol/acetonitrile and purified by preparative HPLC (RP18 column, mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid). this gave 22 mg (34% of theory; purity: 100%) of the title compound.

Provenance & Evidence