m-Chloroperbenzoic acid → HCID 86680833, compound

Participants

Reaction Steps

To a mixture of 0.38 g of 3-chloro-4-[5-(trifluoromethyl)benzofuran-2-yl]pyridine and 4 ml of chloroform was added 0.41 g of 70% m-chloroperbenzoic acid under ice-cooling. This mixture was stirred under ice-cooling for 30 minutes and subsequently at room temperature for 2 hours. The reaction mixture was diluted with chloroform, and sequentially washed with a 5% aqueous solution of sodium hydroxide and saturated brine. The organic layer was dried over magnesium sulfate, then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.32 g of 3-chloro-4-[5-(trifluoromethyl)benzofuran-2-yl]pyridine 1-oxide (hereinafter, referred to as “Present Active Compound 7”).

Provenance & Evidence