3-(Trifluoromethyl)phenol → HCID 70652002, compound

Participants

Reaction Steps

A mixture of 10 g of 3-(trifluoromethyl)phenol and 15 ml of DMF was added dropwise to a mixture of 2.71 g of sodium hydride (60%, oil-based) and 45 ml of DMF under ice-cooling, and the mixture was stirred for 30 minutes. Subsequently, a mixture of 7.0 g of chloromethyl ethyl ether and 5 ml of DMF was added dropwise thereto, and the mixture was stirred for 1 hour. The reaction mixture was added to ice water. This mixture was extracted twice with ethyl acetate. The organic layers were combined and washed with water and saturated brine and dried over magnesium sulfate, then concentrated under reduced pressure, to obtain 13 g of 1-ethoxymethoxy-3-(trifluoromethyl)benzene.

Provenance & Evidence