Acetone → 2-Hydroxy-4-(trifluoromethyl)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.90 g of 2-ethoxymethoxy-4-trifluoromethylbenzaldehyde, 10 ml of acetone, and 9 ml of 6 N hydrochloric acid was stirred at room temperature for 3 hours and subsequently at 40° C. for 1 hour. The reaction mixture was cooled to room temperature, then water was added to the reaction mixture. This mixture was extracted twice with ethyl acetate. The organic layers were combined and washed with water and saturated brine and dried over magnesium sulfate, then concentrated under reduced pressure, to obtain 1.05 g of 2-hydroxy-4-(trifluoromethyl)benzaldehyde.

Provenance & Evidence