Ethanol → (3-Fluoropyridin-4-yl)methanol

To a mixture of 1.2 g of 3-fluoroisonicotinaldehyde and 5 ml of ethanol was gradually added 0.36 g of sodium borohydride under ice-cooling, and the mixture was stirred under ice-cooling for 3 hours. Water was added to the reaction mixture, and the mixture was extracted twice with ethyl acetate. The organic layers were combined and washed with saturated brine and dried over magnesium sulfate. The resulting mixture was concentrated under reduced pressure to obtain 1.12 g of (3-fluoropyridin-4-yl)methanol.

1. temperaturecooling
2. temperaturecooling for 3 hours
3. extractionthe mixture was extracted twice with ethyl acetate
4. washwashed with saturated brine
5. dry with materialdried over magnesium sulfate
6. concentrationThe resulting mixture was concentrated under reduced pressure

ORD record

ord-7cc93218c479482eac1e763c530609b2

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08796306B2