2-Aminopyridine → HCID 58869795, compound

HRID 2402281Notes

Reaction equation

HRID 2402281 reaction equation
[CH2:1]([N:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]1[CH2:18][CH2:19][C:20]([NH:22][C:23]1S[CH:25]=[CH:26][N:27]=1)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C:29]1[CH:34]=CC=CN=1>>[CH2:1]([N:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]1[CH2:18][CH2:19][C:20]([NH:22][C:23]1[CH:34]=[CH:29][CH:25]=[CH:26][N:27]=1)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 104392-AminopyridineHCID 58869823HCID 58869823, compound

Product 1

HCID 58869795HCID 58869795, compound

Procedure

The product from Example 1, Part E (200 mg, 0.68 mmol) and 2-aminopyridine (95 mg, 1.02 mmol) were converted to the title compound in a manner analogous to the method described in Example 2 (10 mg, 4%). 1H NMR (300 MHz, acetone-d6) δ 9.13 (br s, 1H), 8.02 (m, 2H), 7.63 (m, 2H), 7.48 (m, 3H), 7.20 (m, 5H), 6.91 (m, 1H), 5.13 (d, J=15 Hz, 1H), 4.48 (m, 1H), 4.24 (d, J=15 Hz, 1H), 2.35 (m, 2H), 1.84 (m, 2H). MS: m/z (MH+) 372.

Sources & evidence

ORD record
ord-11e4a8ee55a0409c91421b6fa9232b49
Source dataset
uspto-grants-2014_08
Patent number
US08796313B2

Reaction notes

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