Methanol → HCID 12837909, compound

Participants

Reaction Steps

To a solution of (3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetic acid (2.0 g, 10.4 mmol) in 100 mL methanol was added 2 mL conc. H2SO4 over 5 min. The mixture was stirred at room temperature for 16 h. Solvent was evaporated, the crude oil was dissolved in 200 mL EtOAc, then washed with 50 mL sat'd NaHCO3 and 2×50 mL water. The organic phase was dried (Na2SO4), filtered, and solvent was evaporated. The title compound was isolated as a yellow oil (2.1 g, 98%).

Provenance & Evidence