Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | 3-Fluorophthalic anhydride | HCID 69551 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 67482283 | HCID 67482283 | 104.6% |
Reaction Steps
A mixture of 3-fluorophthalic anhydride (20 g, 120 mmol) and 4-fluorobenzylamine (20 g, 160 mmol) was stirred in 150 mL toluene. Glacial acetic acid (4 mL) was added dropwise, and the reaction was stirred at 110° C. Water was trapped with a Dean-Stark trap for 16 h. The reaction was cooled to 0° C. Product was isolated by filtration as an off-white solid, after washing with hexane. Obtain the title compound (34.3 g, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08796313B2 |
|---|
| Source dataset | uspto-grants-2014_08 |
|---|
| ORD ID | ord-81325a4260a24b58ab914825c0acc0de |
|---|
| Source note | uspto-grants-2014_08 |
|---|
