4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 86612285, compound

HRID 2402294Notes

Reaction equation

HRID 2402294 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[C:4](=[O:35])[N:5]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)[CH:6]2[CH2:12][CH2:13][C:14](NC1C=CC(C(F)(F)F)=CN=1)=[O:15].[CH2:36]([O:38][C:39](=[O:47])[CH2:40][C:41]1[N:42]=[C:43]([NH2:46])[S:44][CH:45]=1)[CH3:37]>>[CH2:36]([O:38][C:39](=[O:47])[CH2:40][C:41]1[N:42]=[C:43]([NH:46][C:14](=[O:15])[CH2:13][CH2:12][CH:6]2[C:7]3[C:3](=[C:2]([F:1])[CH:10]=[CH:9][C:8]=3[F:11])[C:4](=[O:35])[N:5]2[CH2:27][C:28]2[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=2)[S:44][CH:45]=1)[CH3:37]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 58869805HCID 58869805, compound

Product 1

HCID 86612285HCID 86612285, compound

Procedure

The product from Example 18, Part A (100 mg, 0.29 mmol) and (2-amino-4-thiazolyl)acetic acid ethyl ester was converted to the title compound in a manner analogous to the method described in Example 7, Part E without crystallization (70 mg, 47%).

Sources & evidence

ORD record
ord-7a4c7d0df0664ce7ab16d2564511e1eb
Source dataset
uspto-grants-2014_08
Patent number
US08796313B2

Reaction notes

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