Water → HCID 67482536, compound

Participants

Reaction Conditions

Reaction Steps

Bromomethyl methyl ether (0.25 mL, 3.06 mmol) was added dropwise to a cold (0° C.) solution of the compound prepared in Part A (0.222 g, 1.79 mmol) and N,N-diisopropylethylamine (0.47 mL, 2.68 mmol) in CH2Cl2 (10 mL). The resulting mixture stirred at 0° C. for 2½ hr, water was added and layers separated. The CH2Cl2 layer was dried over MgSO4, filtered and evaporated in vacuo to give the desired MOM protected amino pyridine product.

Provenance & Evidence