2-Amino-5-methylpyridine → HCID 16663093, compound

Participants

Reaction Steps

The product from Example 11, Part D (120 mg, 0.36 mmol) and 5-methylpyridin-2-ylamine (39 mg, 0.36 mmol) were converted to the title compound in a manner analogous to the method described in Example 27 (78 mg, 50%). 1H NMR (400 MHz, CDCl3) δ 8.27 (s, 1H), 7.99 (d, J=8 Hz, 1H), 7.94 (s, 1H), 7.66 (d, J=7 Hz, 1H), 7.49 (dd, J=8 Hz, 2 Hz, 1H), 7.43 (m, 1H), 7.30 (m, 2H), 7.17 (t, J=9 Hz, 1H), 7.00 (t, J=7 Hz, 2H), 5.26 (d, J=15 Hz, 1H), 4.68 (m, 1H), 4.21 (d, J=15 Hz, 1H), 2.55 (m, 2H), 2.27 (s, 3H), 1.92 (m, 2H). MS: m/z (MH+) 422.

Provenance & Evidence