6-Amino-3-chloropyridazine → HCID 58869810, compound

Participants

Reaction Steps

The product of Example 11, Part D (150 mg, 0.453 mmol) and 3-amino-6-chloropyridazine (57.3 mg, 0.453 mmol) were converted to the title compound in a manner analogous to the method described in Example 27 (112 mg, 18%). 1H NMR (400 MHz, CDCl3) δ 9.71 (s, 1H), 8.45 (d, J=9 Hz, 1H), 7.61 (d, J=8 Hz, 1H); 7.49 (d, J=9 Hz, 1H); 7.39 (m, 1H); 7.30 (m, 2H), 7.17 (t, J=9 Hz, 1H); 7.01 (t, J=8.5 Hz, 2H); 5.29 (d, J=15 Hz, 1H), 4.69 (m, 1H), 4.25 (d, J=15 Hz, 1H), 2.63-2.52 (m, 2H); 2.29-2.17 (m, 2H). MS: m/z (MH+) 443.

Provenance & Evidence