2-Amino-5-chloropyridine → HCID 58869804, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-5-chloropyridine	HCID 66174	—
Reactant	6-{3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionylamino}-nicotinic acid	HCID 16058717	—
Product	HCID 58869804	HCID 58869804	—

Reaction Steps

The product of Example 11, Part D (120 mg, 0.45 mmol) and 2-amino-5-chloropyridine (58 mg, 0.45 mmol) were converted to the title compound in a manner analogous to the method described in Example 27 (85 mg, 49%). 1H NMR (400 MHz, CDCl3) δ 8.12 (s, 1H), 8.09 (d, J=8.7 Hz, 1H), 7.81 (s, 1H); 7.69-7.61 (m, 3H); 7.48-7.43 (m, 1H); 7.35 (m, 2H), 7.26 (t, J=8.8 Hz, 1H); 7.17 (t, J=8.5 Hz, 2H); 5.28 (d, J=15 Hz, 1H), 4.69 (s, 1H), 4.26 (d, J=15 Hz, 1H), 2.59-2.48 (m, 2H); 1.98-1.90 (m, 2H). MS: m/z (MH+) 443.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08796313B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-8aae6c9ab1e1402bbfac2fb194e277aa
Source note	uspto-grants-2014_08